Electroweak Symmetry Breaking due to Confinement

Within the framework of gauge mediated supersymmetry breaking, we consider an electroweak symmetry breaking pattern in which there is no conventional $\mu$ term. The pattern is made appealing through realizing it as low energy effective description of a supersymmetric Yang-Mills theory which is of confinement. Phenomenological implications are discussed.Comment: 8 pages, revtex, no figure, the discussion on effective superpotential refine

IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a major nosocomial pathogen that is widespread in both health-care facilities and in the community at large, as a result of direct host-to-host transmission. Several virulence factors are associated with pathogen transmission to naive hosts. Immunodominant surface antigen B (IsaB) is a virulence factor that helps Staphylococcus aureus to evade the host defense system. However, the mechanism of IsaB on host transmissibility remains unclear. We found that IsaB expression was elevated in transmissible MRSA. Wild-type isaB strains inhibited autophagic flux to promote bacterial survival and elicit inflammation in THP-1 cells and mouse skin. MRSA isolates with increased IsaB expression showed decreased autophagic flux, and the MRSA isolate with the lowest IsaB expression showed increased autophagic flux. In addition, recombinant IsaB rescued the virulence of the isaB deletion strain and increased the group A streptococcus (GAS) virulence in vivo. Together, these results reveal that IsaB diminishes autophagic flux, thereby allowing MRSA to evade host degradation. These findings suggest that IsaB is a suitable target for preventing or treating MRSA infection

The Numerical Solution of Scalar Field for Nariai Case in 5D Ricci-flat SdS Black String Space with Polynomial Approximation

As one exact candidate of the higher dimensional black hole, the 5D Ricci-flat Schwarzschild-de Sitter black string space presents something interesting. In this paper, we give a numerical solution to the real scalar field around the Nariai black hole by the polynomial approximation. Unlike the previous tangent approximation, this fitting function makes a perfect match in the leading intermediate region and gives a good description near both the event and the cosmological horizons. We can read from our results that the wave is close to a harmonic one with the tortoise coordinate. Furthermore, with the actual radial coordinate the waves pile up almost equally near the both horizons.Comment: 8 pages, 4 figure

Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves.

Transgene introgression is a major concern associated with transgenic plant-based vaccines. Agroinfiltration can be used to selectively transform nonreproductive organs and avoid introgression. Here, we introduce a new vaccine modality in which Staphylococcal enterotoxin B (SEB) genes are agroinfiltrated into radishes (Raphanw sativus L.), resulting in transient expression and accumulation of SEB in planta. This approach can simultaneously express multiple antigens in a single leaf. Furthermore, the potential of high-throughput vaccine production was demonstrated by simultaneously agroinfiltrating multiple radish leaves using a multichannel pipette. The expression of SEB was detectable in two leaf cell types (epidermal and guard cells) in agroinfiltrated leaves. ICR mice intranasally immunized with homogenized leaves agroinfiltrated with SEB elicited detectable antibody to SEB and displayed protection against SEB-induced interferon-gamma (IFN-γ) production. The concept of encapsulating antigens in leaves rather than purifying them for immunization may facilitate rapid vaccine production during an epidemic disease

Regional Relationship between Macular Retinal Thickness and Corresponding Central Visual Field Sensitivity in Glaucoma Patients

Purpose. To investigate the relationship between macular retinal thickness (MRT) and central visual field sensitivity (VFS) in patients with glaucoma. Methods. This retrospective study enrolled patients diagnosed with open-angle glaucoma. All study patients underwent Humphrey 10-2 visual field (VF) test and Spectralis spectral-domain optical coherence tomography (SD-OCT) exam for MRT measurement. Results. Sixty-eight eyes of 68 patients were examined. The correlation coefficients between VFS and MRT were 0.331 (P=0.006) and 0.491 (P=0.000) in the superior and inferior hemispheres, respectively. The average MRT in the eyes with abnormal 10-2 VF hemifields was significantly thinner than that in the eyes without abnormal hemifields in both hemispheres (P=0.005 and 0.000 in the superior and inferior hemisphere, resp.). The average MRT values with an optimal sensitivity-specificity balance for discriminating the abnormal VF hemifield from the normal hemifield were 273.5 μm and 255.5 μm in the superior and inferior hemisphere, respectively. The area under the receiver operating characteristic curve was 0.701 in the superior hemisphere and 0.784 in the inferior hemisphere (both P<0.05). Conclusions. MRT measured through SD-OCT was significantly correlated with central VFS. Lower MRT values might be a warning sign for central VF defects in glaucoma patients

Longitudinal imaging of microvascular remodelling in proliferative diabetic retinopathy using adaptive optics scanning light ophthalmoscopy

Purpose To characterise longitudinal changes in the retinal microvasculature of type 2 diabetes mellitus (T2DM) as exemplified in a patient with proliferative diabetic retinopathy (PDR) using an adaptive optics scanning light ophthalmoscope (AOSLO). Methods A 35-year-old T2DM patient with PDR treated with scatter pan-retinal photocoagulation at the inferior retina 1 day prior to initial AOSLO imaging along with a 24-year-old healthy control were imaged in this study. AOSLO vascular structural and perfusion maps were acquired at four visits over a 20-week period. Capillary diameter and microaneurysm area changes were measured on the AOSLO structural maps. Imaging repeatability was established using longitudinal imaging of microvasculature in the healthy control. Results Capillary occlusion and recanalisation, capillary dilatation, resolution of local retinal haemorrhage, capillary hairpin formation, capillary bend formation, microaneurysm formation, progression and regression were documented over time in a region 2° superior to the fovea in the PDR patient. An identical microvascular network with same capillary diameter was observed in the control subject over time. Conclusions High-resolution serial AOSLO imaging enables in vivo observation of vasculopathic changes seen in diabetes mellitus. The implications of this methodology are significant, providing the opportunity for studying the dynamics of the pathological process, as well as the possibility of identifying highly sensitive and non-invasive biomarkers of end organ damage and response to treatment

The Gemini NICI Planet-Finding Campaign: The Offset Ring of HR 4796 A

We present J, H, CH_4 short (1.578 micron), CH_4 long (1.652 micron) and K_s-band images of the dust ring around the 10 Myr old star HR 4796 A obtained using the Near Infrared Coronagraphic Imager (NICI) on the Gemini-South 8.1 meter Telescope. Our images clearly show for the first time the position of the star relative to its circumstellar ring thanks to NICI's translucent focal plane occulting mask. We employ a Bayesian Markov Chain Monte Carlo method to constrain the offset vector between the two. The resulting probability distribution shows that the ring center is offset from the star by 16.7+/-1.3 milliarcseconds along a position angle of 26+/-3 degrees, along the PA of the ring, 26.47+/-0.04 degrees. We find that the size of this offset is not large enough to explain the brightness asymmetry of the ring. The ring is measured to have mostly red reflectivity across the JHK_s filters, which seems to indicate micron-sized grains. Just like Neptune's 3:2 and 2:1 mean-motion resonances delineate the inner and outer edges of the classical Kuiper Belt, we find that the radial extent of the HR 4796 A and Fomalhaut rings could correspond to the 3:2 and 2:1 mean-motion resonances of hypothetical planets at 54.7 AU and 97.7 AU in the two systems, respectively. A planet orbiting HR 4796 A at 54.7 AU would have to be less massive than 1.6 Mjup so as not to widen the ring too much by stirring.Comment: Accepted to A&A for publication on April 23, 2014 (15 pages, 9 figures, 4 tables